Astroglial P2X7 receptor current density increased following long-term exposure to rotenone

Increased risk of endometriosis by long term exposure to xenoestrogens: A case control study in Iranian women

Aims of the study: Endometriosis is a prevalent gynecologic disorder in young women at reproductiveage but the underlying risk factors have not identified yet in Iran and other neighboringcountries. Persistent exposure to environmental endocrine disrupting chemicals (EDCs) in particulardioxins, PAHs and polychlorinated biphenyls (PCBs) with xenoestrogenic potentials have beenhypothesized in the...

P2X7 receptor-mediated PARP1 activity regulates astroglial death in the rat hippocampus following status epilepticus

Poly(ADP-ribose) polymerase-1 (PARP1) plays a regulatory role in apoptosis, necrosis, and other cellular processes after injury. Recently, we revealed that PARP1 regulates the differential neuronal/astroglial responses to pilocarpine-induced status epilepticus (SE) in the distinct brain regions. In addition, P2X7 receptor (P2X7R), an ATP-gated ion channel, activation accelerates astroglial apop...

Current Status of Long-term Care in Taiwan: Transition of Long-term Care Plan From 1.0 to 2.0

Long-term changes in mineralocorticoid and glucocorticoid receptor occupancy following exposure to an acute stressor.

Stressors produce rapid activation of the hypothalamic-pituitary-adrenal axis, which typically resolves within 60-90 min following termination of the stressor. In addition, some stressors such as inescapable tailshock (IS) also produce elevated basal levels of corticosterone (CORT), and reduced serum levels of corticosteroid binding globulin (CBG). The elevated basal levels of CORT produced by ...

Histomorphometrical changes of oviduct during the long-term exposure of breeder hens to extra thyroxine

In this research a 100 day long treatment period was considered to unmask the probable adverse effects of long-term induced hyperthyroidism on histomorphometrical attributes of the oviduct in broiler breeder hens. A total of seventy 47-week-old Cobb 500 breeder hens were randomly allotted to two treatment groups (5 replicates of 7 hens each). Thyroxine (T4) was orally administered to the hypert...